Below are some videos meant to help give non-biologists a bit of a rough and ready insight into the sorts of data Congenica deal with in the Sapientia application and what they represent. The main things to take away are the concepts from the central dogma and SNV/mutation sections. The cell processes videos are left in just for fun, they are filled with unimportant jargon but might impress you with just how complex and mechanical your cells are at the level of protein molecules.
DNA replication https://www.youtube.com/watch?v=5VefaI0LrgE
How transcription works DNA (a gene) -> mRNA (a transcript): https://www.youtube.com/watch?v=5MfSYnItYvg
How splicing works pre-splice mRNA -> mature mRNA essentially what we refer to when talking about the CDS in the database and back end of Sapientia. https://www.youtube.com/watch?v=aVgwr0QpYNE
How translation works mature mRNA (transcript) -> a nascent (fresh off the press) protein: https://www.youtube.com/watch?v=8dsTvBaUMvw
What does a protein look like, understand how it folds after being produced in translation from mRNA: https://www.youtube.com/watch?v=yZ2aY5lxEGE
Protein posttranslational modification https://www.youtube.com/watch?v=gm-I1OVhB54
Epigenetics i.e. modification of histone proteins and DNA backbone https://www.youtube.com/watch?v=mHak9EZjySs including X linked inactivation https://www.youtube.com/watch?v=Tj_6DcUTRnM
Full lecture on genetic, epigenetics and disease https://www.youtube.com/watch?v=SHpfkNRscOc
Transcription factors, proteins that promote the initiation of transcription as described in the previous video. https://www.youtube.com/watch?v=MkUgkDLp2iE
Little lecture on mutations in general includes SNVs and more complex structural mutations: https://www.youtube.com/watch?v=eDbK0cxKKsk
Diabetes caused inflammation https://www.youtube.com/watch?v=iyUoQ70ZmuQ
Insulin insensitivity https://www.youtube.com/watch?v=VbwRYFMPZS4
Your immune cells can usually trigger another of your cells to die if they sense something is wrong. This process of cell death is called apoptosis. Many cancers are caused by a somatic mutation in your cells that prevents this death signal cascading in sick cells. The video below shows you an animation of one of these pathways to cell death. If any of the genes that produce the molecules involved becomes highly mutated it could stop the death signal from doing what you see in the video: https://www.youtube.com/watch?v=DR80Huxp4y8
Homologous recombination and double strand break repair. If a DNA double helix breaks complete apart at a single point the other chromatid (i.e. the one from your other parent) is used as a template to copy against and bridge the repair. This is one mechanism of inserts in the genome when it goes a bit wrong. https://www.youtube.com/watch?v=86JCMM5kb2A
End joining double strand break repair. The two ends of the double helix are cleaned up and joined back together again. This is one of the main mechanism of genomic deletions. https://www.youtube.com/watch?v=31stiofJjYw
The following videos are quite accurate for how the molecules look and act in your cells. However, there is a big BUT with this. If you had everything that is in your cells portrayed you wouldn't be able to see anything in the video, apart from a hot mess. Your cells are utterly packed almost solid with proteins and other small molecules at this scale. The videos only show bits and pieces from very well understood 'pathways' where each protein is understood and how they interact.
A super detailed overview of what happens when your white blood cells respond to inflamed tissue along the wall of a blood vessel: https://www.youtube.com/watch?v=FzcTgrxMzZk
An accurate view of bits of the kinetochore and chromosomes splitting apart when cells divide: https://www.youtube.com/watch?v=0JpOJ4F4984