Short answer: Use skip nav links in conjunction with coherent heading outline and ARIA Landmarks, and be aware of browser support.
It can be frustrating and fatiguing for folks with limited mobility to have to have to repeatedly tab through navigation links to get to the main content of a page. People who use screen readers face similar frustration with repetitive content on poorly structured pages. In order to address this issue, WCAG 2.0 has specified a guideline for bypassing blocks of content that are repeated across multiple pages.
A classic approach to fulfilling this requirement has been to include a [skip navigation link][1] at the beginning of the page, that changes focus to the first element after the repeated content.
<body>
<a href="#main">Skip to main content</a>
<nav role='navigation'>