Here are 10 key takeaways from the video transcript in concise, informative statements:

1. Flight 370 disappeared from radar after its transponder was turned off at 1:21am on March 8, 2014 while at waypoint IGARI.

2. The plane turned back towards Malaysia, avoiding detection by military radar.

3. At 2:25am, the plane's satellite data unit rebooted, creating the first of 7 "handshake" arcs showing the plane's location.

4. The plane continued flying for hours after disappearing from radar.

5. The cabin was depressurized at 1:21am, likely rendering all passengers unconscious.

6. The first officer was locked out of the cockpit after being sent to get coffee.

7. At 2:22am, the plane turned south towards the Indian Ocean.

8. The captain had practiced this route on his home flight simulator in February 2014.

9. The plane ran out of fuel and crashed in the southern Indian Ocean at 8:19am.

10. 30 pieces of debris from MH370 have washed up on beaches, confirming it went down in the Indian Ocean.